Find a way to control heart disease with MEMS chip

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Using MEMS chips to find ways to control heart disease

eetimes Florida reported that the study of the causes and prevention of cardiovascular disease will not be limited to dissecting rats or cultivating heart cells in Petri dishes in the future. At Nanyang Technological University in Singapore, medical researchers are trying to achieve this goal by using a newly developed micro electro mechanical system (MEMS) microfluidic chip, which can complete the mechanical property experiments of tapes, chains, steel wires, electrodes and components

the chip simulates the precise blood flow in the artery when fat and cholesterol accumulate on the internal artery wall plaque. In living tissue, the resulting atherosclerosis will restrict blood flow and may lead to heart attack. This kind of core is naturally insightful and clear. The best thing about this piece is that it can simulate the inflammatory reaction of cardiac vascular cells, which can cut off the blood supply. If these reactions can be suppressed, heart disease will not happen

in the experiment, researchers first used artificial blood to improve the flow channel through microfluidic "blood vessels", and then used real blood to simulate the inflammatory reaction that needs to be eliminated to prevent heart attack. Because the response of cells in the inner wall of blood vessels can be closely observed on the chip, the research team claims that their atherosclerosis modeling method is far better than using cultured cells or laboratory animals to simulate conditions

the team hopes to learn how to regulate vasoconstriction by various means, so that the reporter saw the vehicles carrying products to prevent or at least reduce heart attacks. So far, researchers have focused on the overall biomechanics of cardiac blood flow, and accurately simulated the shape and geometry of cardiac blood vessels to find out the cause of vasoconstriction

the chip between only square inches has two stacked chambers separated by flexible polymer membranes to simulate the conditions that lead to heart attack. The bottom chamber contains compressed air and the top chamber contains blood (or blood sample test fluid). To accurately simulate a real heart, researchers cultured endothelial cells from coronary veins and filled the fluid filled chamber. The system operates by pumping air into a flexible plenum, which pushes the membrane to simulate restricted blood flow in blocked arteries

realize the simulation of atherosclerosis on the chip, and evaluate the stenosis of blood vessels and the health status of blood before heart attack.

researchers found that with the aggravation of vascular blockage, endothelial cells release a protein that leads to atherosclerosis. When using real blood simulation, the accumulation of immune cells developed faster into lipids that blocked plaques in arteries

according to Han Weihou, head of chip research and development, the chip is imitating the accuracy of these well-known precursors of heart disease, making it an ideal device for testing new therapies

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